TY - JOUR T1 - Bilateral Cavitations of Ganglionic Eminence: A Fetal MR Imaging Sign of Halted Brain Development JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A3508 AU - A. Righini AU - C. Frassoni AU - F. Inverardi AU - C. Parazzini AU - D. Mei AU - C. Doneda AU - T.J. Re AU - I. Zucca AU - R. Guerrini AU - R. Spreafico AU - F. Triulzi Y1 - 2013/04/18 UR - http://www.ajnr.org/content/early/2013/04/18/ajnr.A3508.abstract N2 - SUMMARY: Ganglionic eminence is the main transitory proliferative structure of the ventral telencephalon in human fetal brain and it contributes for at least 35% to the population of cortical interneurons; however data on the human GE anomalies are scarce. We report 5 fetal MR imaging observations with bilateral symmetric cavitations in their GE regions resembling an inverted open C shape and separating the GE itself form the deeper parenchyma. Imaging, neuropathology, and follow-up features suggested a malformative origin. All cases had in common characteristics of lissencephaly with agenesis or severe hypoplasia of corpus callosum of probable different genetic basis. From our preliminary observation, it seems that GE cavitations are part of conditions which are also accompanied by severe cerebral structure derangement. Abbreviations CCcorpus callosumGAgestational ageGEganglionic eminence ER -