PT  - JOURNAL ARTICLE
AU  - C Hecht-Leavitt
AU  - R I Grossman
AU  - W J Curran, Jr
AU  - J T McGrath
AU  - D N Biery
AU  - P M Joseph
AU  - D F Nelson
TI  - MR of brain radiation injury: experimental studies in cats.
DP  - 1987 May 01
TA  - American Journal of Neuroradiology
PG  - 427--430
VI  - 8
IP  - 3
4099  - http://www.ajnr.org/content/8/3/427.short
4100  - http://www.ajnr.org/content/8/3/427.full
SO  - Am. J. Neuroradiol.1987 May 01; 8
AB  - Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV administration of gadolinium-DTPA. An additional lesion in one of these cats displayed high signal on T2-weighted images and enhanced on T1-weighted images after IV gadolinium-DTPA. Pathologic correlation revealed that the nonenhancing T2-weighted lesions consisted of edema or demyelinated regions without inflammation while the gadolinium-enhanced lesion demonstrated necrosis with inflammatory infiltrate. Focal brain irradiation may produce noninflammatory demyelination and necrosis. These histologic entities may be potentially distinguished on MR with IV gadolinium-DTPA.