RT Journal Article
SR Electronic
T1 MR of brain radiation injury: experimental studies in cats.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 427
OP 430
VO 8
IS 3
A1 C Hecht-Leavitt
A1 R I Grossman
A1 W J Curran, Jr
A1 J T McGrath
A1 D N Biery
A1 P M Joseph
A1 D F Nelson
YR 1987
UL http://www.ajnr.org/content/8/3/427.abstract
AB Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV administration of gadolinium-DTPA. An additional lesion in one of these cats displayed high signal on T2-weighted images and enhanced on T1-weighted images after IV gadolinium-DTPA. Pathologic correlation revealed that the nonenhancing T2-weighted lesions consisted of edema or demyelinated regions without inflammation while the gadolinium-enhanced lesion demonstrated necrosis with inflammatory infiltrate. Focal brain irradiation may produce noninflammatory demyelination and necrosis. These histologic entities may be potentially distinguished on MR with IV gadolinium-DTPA.