TY - JOUR T1 - Abnormal Cerebral Microstructure in Premature Neonates with Congenital Heart Disease JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A3528 AU - L.B. Paquette AU - J.L. Wisnowski AU - R. Ceschin AU - J.D. Pruetz AU - J.A. Detterich AU - S. Del Castillo AU - A.C. Nagasunder AU - R. Kim AU - M.J. Painter AU - F.H. Gilles AU - M.D. Nelson AU - R.G. Williams AU - S. Blüml AU - A. Panigrahy Y1 - 2013/05/23 UR - http://www.ajnr.org/content/early/2013/06/06/ajnr.A3528.abstract N2 - BACKGROUND AND PURPOSE: Abnormal cerebral microstructure has been documented in term neonates with congenital heart disease, portending risk for injury and poor neurodevelopmental outcome. Our hypothesis was that preterm neonates with congenital heart disease would demonstrate diffuse cerebral microstructural abnormalities when compared with critically ill neonates without congenital heart disease. A secondary aim was to identify any association between microstructural abnormalities, white matter injury (eg, punctate white matter lesions), and other clinical variables, including heart lesions. MATERIALS AND METHODS: With the use of tract-based spatial statistics, an unbiased, voxelwise method for analyzing diffusion tensor imaging data, we compared 21 preterm neonates with congenital heart disease with 2 cohorts of neonates without congenital heart disease: 28 term and 27 preterm neonates, identified from the same neonatal intensive care unit. RESULTS: Compared with term neonates without congenital heart disease, preterm neonates with congenital heart disease had microstructural abnormalities in widespread regions of the central white matter. However, 42% of the preterm neonates with congenital heart disease had punctate white matter lesions. When neonates with punctate white matter lesions were excluded, microstructural abnormalities remained only in the splenium. Preterm neonates with congenital heart disease had similar microstructure to preterm neonates without congenital heart disease. CONCLUSIONS: Diffuse microstructural abnormalities were observed in preterm neonates with congenital heart disease, strongly associated with punctate white matter lesions. Independently, regional vulnerability of the splenium, a structure associated with visual spatial function, was observed in all preterm neonates with congenital heart disease. Abbreviations CHDcongenital heart diseasepWMLpunctate white matter lesionTBSStract-based spatial statisticsFAfractional anisotropy ER -