RT Journal Article
SR Electronic
T1 An Expanded Role for Neuroimaging in the Evaluation of Memory Impairment
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A3644
A1 R.S. Desikan
A1 M.S. Rafii
A1 J.B. Brewer
A1 C.P. Hess
YR 2013
UL http://www.ajnr.org/content/early/2013/06/13/ajnr.A3644.abstract
AB SUMMARY: Alzheimer disease affects millions of people worldwide. The neuropathologic process underlying this disease begins years, if not decades, before the onset of memory decline. Recent advances in neuroimaging suggest that it is now possible to detect Alzheimer-associated neuropathologic changes well before dementia onset. Here, we evaluate the role of recently developed in vivo biomarkers in the clinical evaluation of Alzheimer disease. We discuss how assessment strategies might incorporate neuroimaging markers to better inform patients, families, and clinicians when memory impairment prompts a search for diagnosis and management options. Abbreviations ADAlzheimer diseaseAPOE ε4apolipoprotein ε4FTDfrontotemporal dementiaMCImild cognitive impairmentNFTsneurofibrillary tanglesPIBPittsburgh Compound-BvMRIvolume-based MR imagingamyloid-βAβ