@article {Duncan, author = {A.F. Duncan and A. Caprihan and E.Q. Montague and J. Lowe and R. Schrader and J.P. Phillips}, title = {Regional Cerebral Blood Flow in Children From 3 to 5 Months of Age}, year = {2013}, doi = {10.3174/ajnr.A3728}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: Understanding the relationship between brain and behavior in early childhood requires a probe of functional brain development. We report the first large study of regional CBF by use of arterial spin-labeling in young children. MATERIALS AND METHODS: Cerebral blood flow by use of arterial spin-labeling was measured in 61 healthy children between the ages of 3 and 5 months. Blood flow maps were parcellated into 8 broadly defined anatomic regions of each cerebral hemisphere. RESULTS: There was no sex effect; however, group analysis demonstrated significantly greater CBF in the sensorimotor and occipital regions compared with dorsolateral prefrontal, subgenual, and orbitofrontal areas (P \< .0001). A significant age effect was also identified, with the largest increase in blood flow between 3 and 5 months occurring in the following regions: orbitofrontal (P \< .009), subgenual (P \< .002), and inferior occipital lobe (P = .001). CONCLUSIONS: These results are consistent with prior histologic studies demonstrating regional variation in brain maturation and suggest that arterial spin-labeling is sensitive to regional as well as age-related differences in CBF in young children. Abbreviations ASLarterial spin-labeling}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/early/2013/10/03/ajnr.A3728}, eprint = {https://www.ajnr.org/content/early/2013/10/03/ajnr.A3728.full.pdf}, journal = {American Journal of Neuroradiology} }