RT Journal Article
SR Electronic
T1 Should Patients with Autosomal Dominant Polycystic Kidney Disease Be Screened for Cerebral Aneurysms?
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A3437
A1 M.N. Rozenfeld
A1 S.A. Ansari
A1 A. Shaibani
A1 E.J. Russell
A1 P. Mohan
A1 M.C. Hurley
YR 2013
UL http://www.ajnr.org/content/early/2013/01/04/ajnr.A3437.abstract
AB SUMMARY: Autosomal dominant polycystic kidney disease is a genetic disorder affecting 1 in 1000 people worldwide and is associated with an increased risk of intracranial aneurysms. It remains unclear whether there is sufficient net benefit to screening this patient population for IA, considering recent developments in imaging and treatment and our evolving understanding of the natural history of unruptured aneurysms. There is currently no standardized screening protocol for IA in patients with ADPCKD. Our review of the literature focused on the above issues and presents our appraisal of the estimated value of screening for IA in the setting of ADPCKD. Abbreviations ADPCKDautosomal dominant polycystic kidney diseaseGFRglomerular filtration rateIAintracranial aneurysmQALYquality-adjusted life yearsTOFtime-of-flight