RT Journal Article SR Electronic T1 Central Nervous System Involvement in Adults with Epidemic Hemolytic Uremic Syndrome JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology DO 10.3174/ajnr.A3336 A1 M. Wengenroth A1 J. Hoeltje A1 J. Repenthin A1 T.N. Meyer A1 F. Bonk A1 H. Becker A1 S. Faiss A1 O. Stammel A1 P.P. Urban A1 R. Bruening YR 2013 UL http://www.ajnr.org/content/early/2013/01/10/ajnr.A3336.abstract AB SUMMARY: Hemolytic uremic syndrome is a multisystem disorder that is caused by infection with Shiga-toxin-producing Escherichia coli. HUS affects mainly children and is rare among adults. This retrospective case series analyzes clinical signs and MR imaging findings of 11 adult patients with HUS associated nervous system involvement during the epidemic EHEC outbreak in northern Europe with its epicenter in Hamburg in May 2011. The most prevalent imaging finding was symmetric pointy vasogenic edema of the brain stem in the acute and subacute phases of the disease (n = 5). One patient exhibited additional symmetric mesiotemporal signal changes mimicking limbic encephalitis. Two patients developed subcortical patchy lesions, and 4 subjects did not present with any signal changes. Remarkably, territorial ischemia, signs of hemorrhage, or blood-brain barrier disruption have not been detected. While brain stem lesions were transient and normalized with clinical recovery, supratentorial lesions did not resolve completely at 2-month follow-up examination. Abbreviations EHECenterohemorrhagic Escherichia coliHUShemolytic uremic syndromePRESposterior reversible encephalopathy syndromeSTECShiga toxin–producing E coli