RT Journal Article SR Electronic T1 Comparison of Perfusion, Diffusion, and MR Spectroscopy between Low-Grade Enhancing Pilocytic Astrocytomas and High-Grade Astrocytomas JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology DO 10.3174/ajnr.A3905 A1 M. de Fatima Vasco Aragao A1 M. Law A1 D. Batista de Almeida A1 G. Fatterpekar A1 B. Delman A1 A.S. Bader A1 M. Pelaez A1 M. Fowkes A1 R. Vieira de Mello A1 M. Moraes Valenca YR 2014 UL http://www.ajnr.org/content/early/2014/04/03/ajnr.A3905.abstract AB BACKGROUND AND PURPOSE: The differentiation of pilocytic astrocytomas and high-grade astrocytomas is sometimes difficult. There are limited comparisons in the literature of the advanced MR imaging findings of pilocytic astrocytomas versus high-grade astrocytomas. The purpose of this study was to assess the MR imaging, PWI, DWI, and MR spectroscopy characteristics of pilocytic astrocytomas compared with high-grade astrocytomas. MATERIALS AND METHODS: Sixteen patients with pilocytic astrocytomas and 22 patients with high-grade astrocytomas (8–66 years of age; mean, 36 ± 17 years) were evaluated by using a 1.5T MR imaging unit. MR imaging, PWI, DWI, and MR spectroscopy were used to determine the differences between pilocytic astrocytomas and high-grade astrocytomas. The sensitivity, specificity, and the area under the receiver operating characteristic curve of all analyzed parameters at respective cutoff values were determined. RESULTS: The relative cerebral blood volume values were significantly lower in pilocytic astrocytomas compared with the high-grade astrocytomas (1.4 ± 0.9 versus 3.3 ± 1.4; P = .0008). The ADC values were significantly higher in pilocytic astrocytomas compared with high-grade astrocytomas (1.5 × 10−3 ± 0.4 versus 1.2 × 10−3 ± 0.3; P = .01). The lipid-lactate in tumor/creatine in tumor ratios were significantly lower in pilocytic astrocytomas compared with high-grade astrocytomas (8.3 ± 11.2 versus 43.3 ± 59.2; P = .03). The threshold values ≥1.33 for relative cerebral blood volume provide sensitivity, specificity, positive predictive values, and negative predictive values of 100%, 67%, 87%, and 100%, respectively, for differentiating high-grade astrocytomas from pilocytic astrocytomas. The optimal threshold values were ≤1.60 for ADC, ≥7.06 for lipid-lactate in tumor/creatine in tumor, and ≥2.11 for lipid-lactate in tumor/lipid-lactate in normal contralateral tissue. CONCLUSIONS: Lower relative cerebral blood volume and higher ADC values favor a diagnosis of pilocytic astrocytoma, while higher lipid-lactate in tumor/creatine in tumor ratios plus necrosis favor a diagnosis of high-grade astrocytomas. Abbreviations GBMglioblastoma multiformeHGAhigh-grade astrocytomaHGGhigh-grade gliomaLGGlow-grade gliomaLip-Laclipid-lactatennormal contralateralPApilocytic astrocytomarCBVrelative cerebral blood volumeROCreceiver operating characteristic analysis curvetutumorWHOWorld Health Organization