TY - JOUR T1 - Arterial Spin-Labeling Perfusion MRI Stratifies Progression-Free Survival and Correlates with Epidermal Growth Factor Receptor Status in Glioblastoma JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A4196 AU - X.J. Qiao AU - B.M. Ellingson AU - H.J. Kim AU - D.J.J. Wang AU - N. Salamon AU - M. Linetsky AU - A.R. Sepahdari AU - B. Jiang AU - J.J. Tian AU - S.R. Esswein AU - T.F. Cloughesy AU - A. Lai AU - L. Nghiemphu AU - W.B. Pope Y1 - 2015/01/08 UR - http://www.ajnr.org/content/early/2015/01/08/ajnr.A4196.abstract N2 - BACKGROUND AND PURPOSE: Glioblastoma is a common primary brain tumor with a poor but variable prognosis. Our aim was to investigate the feasibility of MR perfusion imaging by using arterial spin-labeling for determining the prognosis of patients with glioblastoma. MATERIALS AND METHODS: Pseudocontinuous arterial spin-labeling with 3D background-suppressed gradient and spin-echo was acquired before surgery on 53 patients subsequently diagnosed with glioblastoma. The calculated CBF color maps were visually evaluated by 3 independent readers blinded to patient history. Pathologic and survival data were correlated with CBF map findings. Arterial spin-labeling values in tumor tissue were also quantified by using manual fixed-size ROIs. RESULTS: Two perfusion patterns were characterized by visual evaluation of CBF maps on the basis of either the presence (pattern 1) or absence (pattern 2) of substantial hyperperfused tumor tissue. Evaluation of the perfusion patterns was highly concordant among the 3 readers (κ = 0.898, P < .001). Pattern 1 (versus pattern 2) was associated with significantly shorter progression-free survival by Kaplan-Meier analysis (median progression-free survival of 182 days versus 485 days, P < .01) and trended with shorter overall survival (P = .079). There was a significant association between pattern 1 and epidermal growth factor receptor variant III expression (P < .01). CONCLUSIONS: Qualitative evaluation of arterial spin-labeling CBF maps can be used to stratify survival and predict epidermal growth factor receptor variant III expression in patients with glioblastoma. Abbreviations ASLarterial spin-labelingEGFRepidermal growth factor receptorEGFRvIIIepidermal growth factor receptor variant IIIGBMglioblastomaHRhazard ratioOSoverall survivalPFSprogression-free survival ER -