PT - JOURNAL ARTICLE AU - E. Widjaja AU - M. Zamyadi AU - C. Raybaud AU - O.C. Snead AU - S.M. Doesburg AU - M.L. Smith TI - Disrupted Global and Regional Structural Networks and Subnetworks in Children with Localization-Related Epilepsy AID - 10.3174/ajnr.A4265 DP - 2015 Mar 05 TA - American Journal of Neuroradiology 4099 - http://www.ajnr.org/content/early/2015/03/05/ajnr.A4265.short 4100 - http://www.ajnr.org/content/early/2015/03/05/ajnr.A4265.full AB - BACKGROUND AND PURPOSE: Structural connectivity has been thought to be a less sensitive measure of network changes relative to functional connectivity in children with localization-related epilepsy. The aims of this study were to investigate the structural networks in children with localization-related epilepsy and to assess the relation among structural connectivity, intelligence quotient, and clinical parameters. MATERIALS AND METHODS: Forty-five children with nonlesional localization-related epilepsy and 28 healthy controls underwent DTI. Global network (network strength, clustering coefficient, characteristic path length, global efficiency, and small-world parameters), regional network (nodal efficiency), and the network-based statistic were compared between patients and controls and correlated with intelligence quotient and clinical parameters. RESULTS: Patients showed disrupted global network connectivity relative to controls, including reduced network strength, increased characteristic path length and reduced global efficiency, and reduced nodal efficiency in the frontal, temporal, and occipital lobes. Connectivity in multiple subnetworks was reduced in patients, including the frontal-temporal, insula-temporal, temporal-temporal, frontal-occipital, and temporal-occipital lobes. The frontal lobe epilepsy subgroup demonstrated more areas with reduced nodal efficiency and more impaired subnetworks than the temporal lobe epilepsy subgroup. Network parameters were not significantly associated with intelligence quotient, age at seizure onset, or duration of epilepsy. CONCLUSIONS: We found disruption in global and regional networks and subnetworks in children with localization-related epilepsy. Regional efficiency and subnetworks were more impaired in frontal lobe epilepsy than in temporal lobe epilepsy. Future studies are needed to evaluate the implications of disrupted networks for surgical resection and outcomes for specific epileptogenic zones and the relation of disrupted networks to more complex cognitive function. Abbreviations AALautomated anatomic labelingFLEfrontal lobe epilepsyIQintelligence quotientNBSnetwork-based statisticTLEtemporal lobe epilepsy