PT - JOURNAL ARTICLE AU - V. Nambiar AU - S.I. Sohn AU - M.A. Almekhlafi AU - H.W. Chang AU - S. Mishra AU - E. Qazi AU - M. Eesa AU - A.M. Demchuk AU - M. Goyal AU - M.D. Hill AU - B.K. Menon TI - CTA Collateral Status and Response to Recanalization in Patients with Acute Ischemic Stroke AID - 10.3174/ajnr.A3817 DP - 2013 Dec 26 TA - American Journal of Neuroradiology 4099 - http://www.ajnr.org/content/early/2013/12/26/ajnr.A3817.short 4100 - http://www.ajnr.org/content/early/2013/12/26/ajnr.A3817.full AB - BACKGROUND AND PURPOSE: Collateral status at baseline is an independent determinant of clinical outcome among patients with acute ischemic stroke. We sought to identify whether the association between recanalization after intra-arterial acute stroke therapy and favorable clinical response is modified by the presence of good collateral flow assessed on baseline CTA. MATERIALS AND METHODS: Data are from the Keimyung Stroke Registry, a prospective cohort study of patients with acute ischemic stroke from Daegu, South Korea. Patients with M1 segment MCA with or without intracranial ICA occlusions on baseline CTA from May 2004 to July 2009 who also had baseline MR imaging were included. Two readers blinded to all clinical information assessed baseline and follow-up imaging. Leptomeningeal collaterals on baseline CTA were assessed by consensus by use of the regional leptomeningeal score. RESULTS: Among 84 patients (mean age, 65.2 ± 13.2 years; median NIHSS score, 14; interquartile range, 8.5), median time from stroke onset to initial MR imaging was 164 minutes. TICI 2b–3 recanalization was achieved in 38.1% of patients and mRS 0–2 at 90 days in 35.8% of patients. In a multivariable model, the interaction between collateral status and recanalization was significant. Only patients with intermediate or good collaterals who recanalized showed a statistically significant association with good clinical outcome (rate ratio = 3.8; 95% CI, 1.2–12.1). Patients with good and intermediate collaterals who did not achieve recanalization and patients with poor collaterals, even if they achieved recanalization, did not do well. CONCLUSIONS: Patients with good or intermediate collaterals on CTA benefit from intra-arterial therapy, whereas patients with poor collaterals do not benefit from treatment. Abbreviations IATintra-arterial therapyrLMCregional leptomeningeal collateral scoreSDstandard deviation