@article {de Havenon, author = {A. de Havenon and A. Sultan-Qurraie and D. Tirschwell and W. Cohen and J. Majersik and J.B. Andre}, title = {Medial Occipital Lobe Hyperperfusion Identified by Arterial Spin-Labeling: A Poor Prognostic Sign in Patients with Hypoxic-Ischemic Encephalopathy}, year = {2015}, doi = {10.3174/ajnr.A4444}, publisher = {American Journal of Neuroradiology}, abstract = {SUMMARY: Hypoxic-ischemic encephalopathy carries an uncertain prognosis. We sought to retrospectively assess the prognostic value of arterial spin-labeling MR imaging in 22 adult patients diagnosed with hypoxic-ischemic encephalopathy. Quantitative CBF maps were generated from the M0 map, and arterial spin-labeling data on a per-voxel basis were regionally interrogated via visual inspection and ROI placement. Hyperperfusion was defined as regional increases in CBF of \>20\% (relative to global CBF) and/or \>100 mL/100 g/min. Eleven of 22 patients had prominent bilateral medial occipital lobe hyperperfusion, all of whom died before hospital discharge. One patient who had nondistinct arterial spin-labeling hyperperfusion and restricted diffusion survived. Medial occipital lobe hyperperfusion is a distinctive pattern that merits prospective investigation in a cohort of patients with moderate hypoxic-ischemic encephalopathy to determine its predictive ability in patients with a higher likelihood of survival.AbbreviationsASLarterial spin-labelingHIEhypoxic-ischemic encephalopathyMOLHmedial occipital lobe hyperperfusion}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/early/2015/09/03/ajnr.A4444}, eprint = {https://www.ajnr.org/content/early/2015/09/03/ajnr.A4444.full.pdf}, journal = {American Journal of Neuroradiology} }