TY - JOUR T1 - Influence of Resting-State Network on Lateralization of Functional Connectivity in Mesial Temporal Lobe Epilepsy JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A4346 AU - L. Su AU - J. An AU - Q. Ma AU - S. Qiu AU - D. Hu Y1 - 2015/05/28 UR - http://www.ajnr.org/content/early/2015/05/28/ajnr.A4346.abstract N2 - BACKGROUND AND PURPOSE: Although most studies on epilepsy have focused on the epileptogenic zone, epilepsy is a system-level disease characterized by aberrant neuronal synchronization among groups of neurons. Increasingly, studies have indicated that mesial temporal lobe epilepsy may be a network-level disease; however, few investigations have examined resting-state functional connectivity of the entire brain, particularly in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. This study primarily investigated whole-brain resting-state functional connectivity abnormality in patients with mesial temporal lobe epilepsy and right hippocampal sclerosis during the interictal period.MATERIALS AND METHODS: We investigated resting-state functional connectivity of 21 patients with mesial temporal lobe epilepsy with right hippocampal sclerosis and 21 neurologically healthy controls. A multivariate pattern analysis was used to identify the functional connections that most clearly differentiated patients with mesial temporal lobe epilepsy with right hippocampal sclerosis from controls.RESULTS: Discriminative analysis of functional connections indicated that the patients with mesial temporal lobe epilepsy with right hippocampal sclerosis exhibited decreased resting-state functional connectivity within the right hemisphere and increased resting-state functional connectivity within the left hemisphere. Resting-state network analysis suggested that the internetwork connections typically obey the hemispheric lateralization trend and most of the functional connections that disturb the lateralization trend are the intranetwork ones.CONCLUSIONS: The current findings suggest that weakening of the resting-state functional connectivity associated with the right hemisphere appears to strengthen resting-state functional connectivity on the contralateral side, which may be related to the seizure-induced damage and underlying compensatory mechanisms. Resting-state network–based analysis indicated that the compensatory mechanism among different resting-state networks may disturb the hemispheric lateralization.AbbreviationsDMNdefault-mode networkFCfunctional connectivity or connectionHShippocampal sclerosismTLEmesial temporal lobe epilepsyR-mTLEmesial temporal lobe epilepsy with right hippocampal sclerosisRSresting-stateRSNresting-state networkTLEtemporal lobe epilepsy ER -