@article {Smith, author = {P. Smith and L.L. Linscott and S. Vadivelu and B. Zhang and J.L. Leach}, title = {Normal Development and Measurements of the Occipital Condyle-C1 Interval in Children and Young Adults}, year = {2015}, doi = {10.3174/ajnr.A4543}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: Widening of the occipital condyle-C1 interval is the most specific and sensitive means of detecting atlanto-occipital dislocation. Recent studies attempting to define normal measurements of the condyle-C1 interval in children have varied substantially. This study was performed to test the null hypothesis that condyle-C1 interval morphology and joint measurements do not change as a function of age.MATERIALS AND METHODS: Imaging review of subjects undergoing CT of the upper cervical spine for reasons unrelated to trauma or developmental abnormality was performed. Four equidistant measurements were obtained for each bilateral condyle-C1 interval on sagittal and coronal images. The cohort was divided into 7 age groups to calculate the mean, SD, and 95\% CIs for the average condyle-C1 interval in both planes. The prevalence of a medial occipital condyle notch was calculated.RESULTS: Two hundred forty-eight joints were measured in 124 subjects with an age range of 2 days to 22 years. The condyle-C1 interval varies substantially by age. Average coronal measurements are larger and more variable than sagittal measurements. The medial occipital condyle notch is most prevalent from 1 to 12 years and is uncommon in older adolescents and young adults.CONCLUSIONS: The condyle-C1 interval increases during the first several years of life, is largest in the 2- to 4-year age range, and then decreases through late childhood and adolescence. A single threshold value to detect atlanto-occipital dissociation may not be sensitive and specific for all age groups. Application of this normative data to documented cases of atlanto-occipital injury is needed to determine clinical utility.AbbreviationCCIoccipital condyle-C1 interval}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/early/2015/10/29/ajnr.A4543}, eprint = {https://www.ajnr.org/content/early/2015/10/29/ajnr.A4543.full.pdf}, journal = {American Journal of Neuroradiology} }