RT Journal Article
SR Electronic
T1 Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A4625
A1 G. Cattaneo
A1 M. Schumacher
A1 C. Maurer
A1 J. Wolfertz
A1 T. Jost
A1 M. Büchert
A1 A. Keuler
A1 L. Boos
A1 M.J. Shah
A1 K. Foerster
A1 W.-D. Niesen
A1 G. Ihorst
A1 H. Urbach
A1 S. Meckel
YR 2016
UL http://www.ajnr.org/content/early/2016/01/14/ajnr.A4625.abstract
AB BACKGROUND AND PURPOSE: Therapeutic hypothermia represents a promising neuroprotective treatment in acute ischemic stroke. Selective cerebral hypothermia applied early, prior to and during endovascular mechanical recanalization therapy, may be beneficial in the critical phase of reperfusion. We aimed to assess the feasibility of a new intracarotid cooling catheter in an animal model.MATERIALS AND METHODS: Nine adult sheep were included. Temperature probes were introduced into the frontal and temporal brain cortices bilaterally. The cooling catheter system was introduced into a common carotid artery. Selective blood cooling was applied for 180 minutes. Systemic and local brain temperatures were measured during cooling and rewarming. Common carotid artery diameters and flow were measured angiographically and by Doppler sonography.RESULTS: The common carotid artery diameter was between 6.7 and 7.3 mm. Common carotid artery blood flow velocities increased moderately during cooling and after catheter removal. Maximum cerebral cooling in the ipsilateral temporal cortex was −4.7°C (95% CI, −5.1 to −4.0°C). Ipsilateral brain temperatures dropped significantly faster and became lower compared with the contralateral cortex with maximum temperature difference of −1.3°C (95% CI, −1.5 to −1.0°C; P < .0001) and compared with systemic temperature (−1.4°C; 95% CI, −1.7 to −1.0°C; P < .0001).CONCLUSIONS: Sheep proved a feasible animal model for the intracarotid cooling catheter. Fast induction of selective mild hypothermia was achieved within the cooled cerebral hemisphere, with stable temperature gradients in the contralateral brain and systemic blood. Further studies are required to demonstrate any therapeutic benefit of selective cerebral cooling in a stroke model.AbbreviationsBWbody weightCCAcommon carotid arteryΔTtemperature dropMTmechanical thrombectomyTHtherapeutic hypothermia