RT Journal Article
SR Electronic
T1 Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A4687
A1 J.I. Berman
A1 D. Chudnovskaya
A1 L. Blaskey
A1 E. Kuschner
A1 P. Mukherjee
A1 R. Buckner
A1 S. Nagarajan
A1 W.K. Chung
A1 E.H. Sherr
A1 T.P.L. Roberts
YR 2016
UL http://www.ajnr.org/content/early/2016/02/11/ajnr.A4687.abstract
AB BACKGROUND AND PURPOSE: Deletion and duplication of chromosome 16p11.2 (BP4–BP5) have been associated with developmental disorders such as autism spectrum disorders, and deletion subjects exhibit a large (20-ms) delay of the auditory evoked cortical response as measured by magnetoencephalography (M100 latency). The purpose of this study was to use a multimodal approach to test whether changes in white matter microstructure are associated with delayed M100 latency.MATERIALS AND METHODS: Thirty pediatric deletion carriers, 9 duplication carriers, and 39 control children were studied with both magnetoencephalography and diffusion MR imaging. The M100 latency and auditory system DTI measures were compared between groups and tested for correlation.RESULTS: In controls, white matter diffusivity significantly correlated with the speed of the M100 response. However, the relationship between structure and function appeared uncoupled in 16p11.2 copy number variation carriers. The alterations to auditory system white matter microstructure in the 16p11.2 deletion only partially accounted for the 20-ms M100 delay. Although both duplication and deletion groups exhibit abnormal white matter microstructure, only the deletion group has delayed M100 latency.CONCLUSIONS: These results indicate that gene dosage impacts factors other than white matter microstructure, which modulate conduction velocity.AbbreviationsASDautism spectrum disorderCNVcopy number variationFAfractional anisotropyHARDIhigh angular resolution diffusion imagingIQintelligence quotientMD=mean diffusivityMEGmagnetoencephalographyRDradial diffusivityVIPVariation in Individuals Project