RT Journal Article
SR Electronic
T1 Hemodynamic and Anatomic Variations Require an Adaptable Approach during Intra-Arterial Chemotherapy for Intraocular Retinoblastoma: Alternative Routes, Strategies, and Follow-Up
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A4741
A1 E. Bertelli
A1 S. Leonini
A1 D. Galimberti
A1 S. Moretti
A1 R. Tinturini
A1 T. Hadjistilianou
A1 S. De Francesco
A1 D.G. Romano
A1 I.M. Vallone
A1 S. Cioni
A1 P. Gennari
A1 P. Galluzzi
A1 I. Grazzini
A1 S. Rossi
A1 S. Bracco
YR 2016
UL http://www.ajnr.org/content/early/2016/02/25/ajnr.A4741.abstract
AB BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma is not always a straightforward procedure, and it may require an adaptable approach. This study illustrates strategies used when the ophthalmic artery is difficult to catheterize or not visible, and it ascertains the effectiveness and safety of these strategies.MATERIALS AND METHODS: A retrospective study was performed on a series of 108 eyes affected by intraocular retinoblastoma and selected for intra-arterial chemotherapy (follow-up range, 6\N82 months). We recognized 3 different patterns of drug delivery: a fixed pattern through the ophthalmic artery, a fixed pattern through branches of the external carotid artery, and a variable pattern through either the ophthalmic or the external carotid artery.RESULTS: We performed 448 sessions of intra-arterial chemotherapy, 83.70% of them through the ophthalmic artery and 16.29% via the external carotid artery. In 24.52% of eyes, the procedure was performed at least once through branches of the external carotid artery. In 73 eyes, the pattern of drug delivery was fixed through the ophthalmic artery; for 9 eyes, it was fixed through branches of the external carotid artery; and for 17 eyes, the pattern was variable. Statistical analysis did not show any significant difference in the clinical outcome of the eyes (remission versus enucleation) treated with different patterns of drug delivery. Adverse events could not be correlated with any particular pattern.CONCLUSIONS: Alternative routes of intra-arterial chemotherapy for intraocular retinoblastoma appear in the short term as effective and safe as the traditional drug infusion through the ophthalmic artery.AbbreviationsECAexternal carotid arteryFPECfixed pattern through the ECAFPOfixed pattern through the OAIACintra-arterial chemotherapyMMAmiddle meningeal arteryOAophthalmic arteryVPvariable pattern