RT Journal Article SR Electronic T1 MR of acute experimental allergic encephalomyelitis. JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1045 OP 1048 VO 8 IS 6 A1 R I Grossman A1 R P Lisak A1 P J Macchi A1 P M Joseph YR 1987 UL http://www.ajnr.org/content/8/6/1045.abstract AB Acute experimental allergic encephalomyelitis, an animal model of CNS inflammatory and demyelinating disease, was produced in guinea pigs and imaged with MR. Correlation of histopathology with MR revealed acute mononuclear perivascular inflammatory changes and edema corresponding to the high-intensity abnormalities observed on long repetition time (TR) images. Our results suggest that in acute multiple sclerosis the high intensity noted on long TR images may be secondary to associated inflammatory changes rather than to demyelination.