PT  - JOURNAL ARTICLE
AU  - S Weis
AU  - G Weber
AU  - A Neuhold
AU  - A Rett
TI  - Down syndrome: MR quantification of brain structures and comparison with normal control subjects.
DP  - 1991 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1207--1211
VI  - 12
IP  - 6
4099  - http://www.ajnr.org/content/12/6/1207.short
4100  - http://www.ajnr.org/content/12/6/1207.full
SO  - Am. J. Neuroradiol.1991 Nov 01; 12
AB  - For quantification of brain structures from MR scans, a novel, powerful stereologic tool known as Cavalieri's principle was applied. This tool enables an objective estimation of volume. The method was applied to detect differences in various brain structures between persons with Down syndrome and control subjects. On the basis of absolute values, smaller volumes for the whole brain, cerebral cortex, white matter, and cerebellum were seen in persons with Down syndrome. Similar results were observed when a normalization procedure, based on the volume of cranial cavity, was used. Stereologic determinations of the volumes of brain structures from MR images can reliably identify volume differences between persons with Down syndrome and control subjects.