PT - JOURNAL ARTICLE AU - L A Hayman AU - K H Taber AU - J J Ford AU - R N Bryan TI - Mechanisms of MR signal alteration by acute intracerebral blood: old concepts and new theories. DP - 1991 Sep 01 TA - American Journal of Neuroradiology PG - 899--907 VI - 12 IP - 5 4099 - http://www.ajnr.org/content/12/5/899.short 4100 - http://www.ajnr.org/content/12/5/899.full SO - Am. J. Neuroradiol.1991 Sep 01; 12 AB - We reviewed the current literature and theories pertaining to the appearance of hemorrhage on MR images. New theories were formulated to explain the etiology of spin-echo (SE) and gradient-echo contrast on clinical MR images of hematomas at low and intermediate field strengths. It is our hope that these theories will prompt further experiments to prove or disprove their validity. The discussion of SE contrast focuses on the powerful MR effects mediated by changes in protein concentration. These changes are postulated to occur as a result of (1) clot matrix formation; (2) settling of RBCs, which increases the number of RBCs per unit volume and the total protein concentration; and (3) alterations in intracellular protein concentration caused by changes in RBC hydration. The contribution of acid methemoglobin to image contrast via the proton electron dipole-dipole mechanism is also included. The discussion of gradient-echo contrast focuses on the inhomogeneity that may be present within voxels that contain a blood clot. This inhomogeneity results when the voxel contains regions with different magnetic susceptibilities (i.e., clumped RBCs and serum). Two temporally arranged schemata for T2-weighted and T1-weighted SE scans are presented that illustrate how these factors might interact to explain the diverse appearance of hematomas on clinical SE images. The signal intensity on T2-weighted SE scans appears to be dependent primarily on the state of hydration of the RBC. This factor and the presence or absence of methemoglobin appear to be the major factors that govern contrast on T1-weighted SE images.