@article {Sen1117, author = {R. Sen and C. Sen and J. Pack and K.T. Block and J.G. Golfinos and V. Prabhu and F. Boada and O. Gonen and D. Kondziolka and G. Fatterpekar}, title = {Role of High-Resolution Dynamic Contrast-Enhanced MRI with Golden-Angle Radial Sparse Parallel Reconstruction to Identify the Normal Pituitary Gland in Patients with Macroadenomas}, volume = {38}, number = {6}, pages = {1117--1121}, year = {2017}, doi = {10.3174/ajnr.A5244}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: Preoperative localization of the pituitary gland with imaging in patients with macroadenomas has been inadequately explored. The pituitary gland enhancing more avidly than a macroadenoma has been described in the literature. Taking advantage of this differential enhancement pattern, our aim was to evaluate the role of high-resolution dynamic MR imaging with golden-angle radial sparse parallel reconstruction in localizing the pituitary gland in patients undergoing trans-sphenoidal resection of a macroadenoma.MATERIALS AND METHODS: A retrospective study was performed in 17 patients who underwent trans-sphenoidal surgery for pituitary macroadenoma. Radial volumetric interpolated brain examination sequences with golden-angle radial sparse parallel technique were obtained. Using an ROI-based method to obtain signal-time curves and permeability measures, 3 separate readers identified the normal pituitary gland distinct from the macroadenoma. The readers{\textquoteright} localizations were then compared with the intraoperative location of the gland. Statistical analyses were performed to assess the interobserver agreement and correlation with operative findings.RESULTS: The normal pituitary gland was found to have steeper enhancement-time curves as well as higher peak enhancement values compared with the macroadenoma (P \< .001). Interobserver agreement was almost perfect in all 3 planes (κ = 0.89). In the 14 cases in which the gland was clearly identified intraoperatively, the correlation between the readers{\textquoteright} localization and the true location derived from surgery was also nearly perfect (κ = 0.95).CONCLUSIONS: This study confirms our ability to consistently and accurately identify the normal pituitary gland in patients with macroadenomas with the golden-angle radial sparse parallel technique with quantitative permeability measurements and enhancement-time curves.ETCenhancement-time curveGRASPgolden-angle radial sparse parallel}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/38/6/1117}, eprint = {https://www.ajnr.org/content/38/6/1117.full.pdf}, journal = {American Journal of Neuroradiology} }