TY - JOUR T1 - Differentiation of Enhancing Glioma and Primary Central Nervous System Lymphoma by Texture-Based Machine Learning JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1145 LP - 1150 DO - 10.3174/ajnr.A5173 VL - 38 IS - 6 AU - P. Alcaide-Leon AU - P. Dufort AU - A.F. Geraldo AU - L. Alshafai AU - P.J. Maralani AU - J. Spears AU - A. Bharatha Y1 - 2017/06/01 UR - http://www.ajnr.org/content/38/6/1145.abstract N2 - BACKGROUND AND PURPOSE: Accurate preoperative differentiation of primary central nervous system lymphoma and enhancing glioma is essential to avoid unnecessary neurosurgical resection in patients with primary central nervous system lymphoma. The purpose of the study was to evaluate the diagnostic performance of a machine-learning algorithm by using texture analysis of contrast-enhanced T1-weighted images for differentiation of primary central nervous system lymphoma and enhancing glioma.MATERIALS AND METHODS: Seventy-one adult patients with enhancing gliomas and 35 adult patients with primary central nervous system lymphomas were included. The tumors were manually contoured on contrast-enhanced T1WI, and the resulting volumes of interest were mined for textural features and subjected to a support vector machine–based machine-learning protocol. Three readers classified the tumors independently on contrast-enhanced T1WI. Areas under the receiver operating characteristic curves were estimated for each reader and for the support vector machine classifier. A noninferiority test for diagnostic accuracy based on paired areas under the receiver operating characteristic curve was performed with a noninferiority margin of 0.15.RESULTS: The mean areas under the receiver operating characteristic curve were 0.877 (95% CI, 0.798–0.955) for the support vector machine classifier; 0.878 (95% CI, 0.807–0.949) for reader 1; 0.899 (95% CI, 0.833–0.966) for reader 2; and 0.845 (95% CI, 0.757–0.933) for reader 3. The mean area under the receiver operating characteristic curve of the support vector machine classifier was significantly noninferior to the mean area under the curve of reader 1 (P = .021), reader 2 (P = .035), and reader 3 (P = .007).CONCLUSIONS: Support vector machine classification based on textural features of contrast-enhanced T1WI is noninferior to expert human evaluation in the differentiation of primary central nervous system lymphoma and enhancing glioma.AUCarea under the receiver operating characteristic curvePCNSLprimary central nervous system lymphomaSVMsupport vector machine ER -