TY - JOUR T1 - Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1555 LP - 1561 DO - 10.3174/ajnr.A5257 VL - 38 IS - 8 AU - A.D. Robertson AU - G. Matta AU - V.S. Basile AU - S.E. Black AU - C.K. Macgowan AU - J.A. Detre AU - B.J. MacIntosh Y1 - 2017/08/01 UR - http://www.ajnr.org/content/38/8/1555.abstract N2 - BACKGROUND AND PURPOSE: The relationship between extracranial large-artery characteristics and arterial spin-labeling MR imaging may influence the quality of arterial spin-labeling–CBF images for older adults with and without vascular pathology. We hypothesized that extracranial arterial blood velocity can explain between-person differences in arterial spin-labeling data systematically across clinical populations.MATERIALS AND METHODS: We performed consecutive pseudocontinuous arterial spin-labeling and phase-contrast MR imaging on 82 individuals (20–88 years of age, 50% women), including healthy young adults, healthy older adults, and older adults with cerebral small vessel disease or chronic stroke infarcts. We examined associations between extracranial phase-contrast hemodynamics and intracranial arterial spin-labeling characteristics, which were defined by labeling efficiency, temporal signal-to-noise ratio, and spatial coefficient of variation.RESULTS: Large-artery blood velocity was inversely associated with labeling efficiency (P = .007), temporal SNR (P < .001), and spatial coefficient of variation (P = .05) of arterial spin-labeling, after accounting for age, sex, and group. Correction for labeling efficiency on an individual basis led to additional group differences in GM-CBF compared to correction using a constant labeling efficiency.CONCLUSIONS: Between-subject arterial spin-labeling variance was partially explained by extracranial velocity but not cross-sectional area. Choosing arterial spin-labeling timing parameters with on-line knowledge of blood velocity may improve CBF quantification.ASLarterial spin-labelingCoVcoefficient of variationPCphase contrastWMHwhite matter hyperintensities ER -