RT Journal Article SR Electronic T1 Brain Structural Changes following HIV Infection: Meta-Analysis JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 54 OP 62 DO 10.3174/ajnr.A5432 VO 39 IS 1 A1 E.E. O'Connor A1 Timothy A. Zeffiro A1 Thomas A. Zeffiro YR 2018 UL http://www.ajnr.org/content/39/1/54.abstract AB BACKGROUND: Numerous studies have used structural neuroimaging to measure HIV effects on brain macroarchitecture. While many have reported changes in total brain volume, gray matter volume, white matter volume, CSF volume, and basal ganglia volume following HIV infection, quantitative inconsistencies observed across studies are large.PURPOSE: Our aim was to evaluate the consistency and temporal stability of serostatus effects on a range of structural neuroimaging measures.DATA SOURCES: PubMed, reference lists, and corresponding authors.STUDY SELECTION: The meta-analysis included 19 cross-sectional studies reporting HIV effects on cortical and subcortical volume from 1993 to 2016.DATA ANALYSIS: Random-effects meta-analysis was used to estimate individual study standardized mean differences and study heterogeneity. Meta-regression was used to examine the effects of the study publication year.DATA SYNTHESIS: Meta-analysis revealed standardized mean differences related to the serostatus of −0.65 (P = .002) for total brain volume, −0.28 for gray matter volume (P = .008), −0.24 (P = .076) for white matter volume, and 0.56 (P = .001) for CSF volume. Basal ganglia volume differences related to serostatus were not significant. Nevertheless, estimates of between-study heterogeneity suggested that much of the observed variance was between studies. Publication year was associated with recent reductions in many neurostructural effects.LIMITATIONS: Many studies pooled participants with varying durations of treatment, disease, and comorbidities. Image-acquisition methods changed with time.CONCLUSIONS: While published studies of HIV effects on brain structure had substantial variations that are likely to result from changes in HIV treatment practice during the study period, quantitative neurostructural measures can reliably detect the effects of HIV infection during treatment, serving as reliable biomarkers.ARTantiretroviral therapyCSFvCSF volumeGMvgray matter volumeSMDstandardized mean differenceTBvtotal brain volumeWMvwhite matter volume