PT  - JOURNAL ARTICLE
AU  - A Bizzi
AU  - A Righini
AU  - R Turner
AU  - D LeBihan
AU  - D DesPres
AU  - G Di Chiro
AU  - J R Alger
TI  - MR of diffusion slowing in global cerebral ischemia.
DP  - 1993 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1347--1354
VI  - 14
IP  - 6
4099  - http://www.ajnr.org/content/14/6/1347.short
4100  - http://www.ajnr.org/content/14/6/1347.full
SO  - Am. J. Neuroradiol.1993 Nov 01; 14
AB  - PURPOSE To investigate the causal connections between ischemia and the hyperintensity in diffusion-weighted MR images that has been associated with it.METHODS Diffusion-weighted and T2-weighted MR imaging were used in a feline global cerebral ischemia/reperfusion model. Single 30-minute vascular occlusions followed by reperfusion were studied. Global occlusions were used to avoid interpretive complications associated with the temporally unstable hemodynamics of the penumbral zones around focal occlusions and the possible growth of the ischemic and penumbral regions with time.RESULTS Diffusion-weighted hyperintensity and the associated diffusional slowing were not attributable exclusively to the cessation of blood flow because: 1) it does not appear abruptly at the onset of ischemia; 2) it resolves slowly early in reperfusion; and 3) it reappears after prolonged reperfusion.CONCLUSION The times during which diffusion-weighted hyperintensity is manifested during ischemia, and recovers with reperfusion, point to a role for energy metabolism failure.