TY - JOUR T1 - Value of Quantitative Collateral Scoring on CT Angiography in Patients with Acute Ischemic Stroke JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1074 LP - 1082 DO - 10.3174/ajnr.A5623 VL - 39 IS - 6 AU - A.M.M. Boers AU - R. Sales Barros AU - I.G.H. Jansen AU - O.A. Berkhemer AU - L.F.M. Beenen AU - B.K. Menon AU - D.W.J. Dippel AU - A. van der Lugt AU - W.H. van Zwam AU - Y.B.W.E.M. Roos AU - R.J. van Oostenbrugge AU - C.H. Slump AU - C.B.L.M. Majoie AU - H.A. Marquering A2 - , Y1 - 2018/06/01 UR - http://www.ajnr.org/content/39/6/1074.abstract N2 - BACKGROUND AND PURPOSE: Many studies have emphasized the relevance of collateral flow in patients presenting with acute ischemic stroke. Our aim was to evaluate the relationship of the quantitative collateral score on baseline CTA with the outcome of patients with acute ischemic stroke and test whether the timing of the CTA acquisition influences this relationship.MATERIALS AND METHODS: From the Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands (MR CLEAN) data base, all baseline thin-slice CTA images of patients with acute ischemic stroke with intracranial large-vessel occlusion were retrospectively collected. The quantitative collateral score was calculated as the ratio of the vascular appearance of both hemispheres and was compared with the visual collateral score. Primary outcomes were 90-day mRS score and follow-up infarct volume. The relation with outcome and the association with treatment effect were estimated. The influence of the CTA acquisition phase on the relation of collateral scores with outcome was determined.RESULTS: A total of 442 patients were included. The quantitative collateral score strongly correlated with the visual collateral score (ρ = 0.75) and was an independent predictor of mRS (adjusted odds ratio = 0.81; 95% CI, .77–.86) and follow-up infarct volume (exponent β = 0.88; P < .001) per 10% increase. The quantitative collateral score showed areas under the curve of 0.71 and 0.69 for predicting functional independence (mRS 0–2) and follow-up infarct volume of >90 mL, respectively. We found significant interaction of the quantitative collateral score with the endovascular therapy effect in unadjusted analysis on the full ordinal mRS scale (P = .048) and on functional independence (P = .049). Modification of the quantitative collateral score by acquisition phase on outcome was significant (mRS: P = .004; follow-up infarct volume: P < .001) in adjusted analysis.CONCLUSIONS: Automated quantitative collateral scoring in patients with acute ischemic stroke is a reliable and user-independent measure of the collateral capacity on baseline CTA and has the potential to augment the triage of patients with acute stroke for endovascular therapy.EVTendovascular therapyFIVfollow-up infarct volumeICA-TICA carotid bifurcationIQRinterquartile rangeMR CLEANMulticenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the NetherlandsqCSquantitative collateral scorevCSvisual collateral score ER -