TY - JOUR T1 - Association of Quantified Location-Specific Blood Volumes with Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1059 LP - 1064 DO - 10.3174/ajnr.A5626 VL - 39 IS - 6 AU - W.E. van der Steen AU - I.A. Zijlstra AU - D. Verbaan AU - A.M.M. Boers AU - C.S. Gathier AU - R. van den Berg AU - G.J.E. Rinkel AU - B.A. Coert AU - Y.B.W.E.M. Roos AU - C.B.L.M. Majoie AU - H.A. Marquering Y1 - 2018/06/01 UR - http://www.ajnr.org/content/39/6/1059.abstract N2 - BACKGROUND AND PURPOSE: Delayed cerebral ischemia is a severe complication of aneurysmal SAH and is associated with a high case morbidity and fatality. The total blood volume and the presence of intraventricular blood on CT after aneurysmal SAH are associated with delayed cerebral ischemia. Whether quantified location-specific (cisternal, intraventricular, parenchymal, and subdural) blood volumes are associated with delayed cerebral ischemia has been infrequently researched. This study aimed to associate quantified location-specific blood volumes with delayed cerebral ischemia.MATERIALS AND METHODS: Clinical and radiologic data were collected retrospectively from consecutive patients with aneurysmal SAH with available CT scans within 24 hours after ictus admitted to 2 academic centers between January 2009 and December 2011. Total blood volume was quantified using an automatic hemorrhage-segmentation algorithm. Segmented blood was manually classified as cisternal, intraventricular, intraparenchymal, or subdural. Adjusted ORs with 95% confidence intervals for delayed cerebral ischemia per milliliter of location-specific blood were calculated using multivariable logistic regression analysis.RESULTS: We included 282 patients. Per milliliter increase in blood volume, the adjusted OR for delayed cerebral ischemia was 1.02 (95% CI, 1.01–1.04) for cisternal, 1.02 (95% CI, 1.00–1.04) for intraventricular, 0.99 (95% CI, 0.97–1.02) for intraparenchymal, and 0.96 (95% CI, 0.86–1.07) for subdural blood.CONCLUSIONS: Our findings suggest that in patients with aneurysmal subarachnoid hemorrhage, the cisternal blood volume has a stronger relation with delayed cerebral ischemia than the blood volumes at other locations in the brain.aORadjusted odds ratioaSAHaneurysmal subarachnoid hemorrhageDCIdelayed cerebral ischemiaIPHintraparenchymal hemorrhageIVHintraventricular hemorrhageSDHsubdural hemorrhageWFNSWorld Federation of Neurosurgical Societies ER -