PT  - JOURNAL ARTICLE
AU  - M. Wang
AU  - H. Liu
AU  - X. Wei
AU  - C. Liu
AU  - T. Liang
AU  - X. Zhang
AU  - C. Jin
AU  - X. Li
AU  - Q. Sun
AU  - H. Jiang
AU  - J. Yang
TI  - Application of Reduced-FOV Diffusion-Weighted Imaging in Evaluation of Normal Pituitary Glands and Pituitary Macroadenomas
AID  - 10.3174/ajnr.A5735
DP  - 2018 Jul 19
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2018/07/19/ajnr.A5735.short
4100  - http://www.ajnr.org/content/early/2018/07/19/ajnr.A5735.full
AB  - BACKGROUND AND PURPOSE: FOV optimized and constrained undistorted single-shot imaging provides relatively high-resolution images with few artifacts. This study evaluated the image quality and value of FOV optimized and constrained undistorted single-shot DWI in the evaluation of normal pituitary glands and pituitary macroadenomas.MATERIALS AND METHODS: Subjects with normal pituitary glands and patients with pituitary macroadenomas underwent FOV optimized and constrained undistorted single-shot and EPI DWI. Two neuroradiologists graded the image quality based on visualization of the pituitary stalk, pituitary gland, and pituitary macroadenoma. Intra- and interobserver agreements were assessed by κ statistics. Image quality and ADCs were compared between the 2 methods by the paired Wilcoxon signed rank test and t test. Differences in ADC between normal pituitary glands and macroadenomas were analyzed by the independent-samples t test.RESULTS: Twenty-eight subjects with normal pituitary glands and 16 patients with macroadenomas were enrolled. Intra- and interobserver agreements for image-quality assessment were moderate to substantial. Relative to EPI DWI, FOV optimized and constrained undistorted single-shot DWI exhibited obviously better image quality both in normal pituitary glands and macroadenomas. There was no significant difference in ADCs of macroadenomas between the 2 methods. Macroadenomas with soft consistency (0.75 ± 0.14 × 10−3 mm2/s) had significantly lower mean ADC than normal pituitary glands (1.18 ± 0.19 × 10−3 mm2/s; P < .001).CONCLUSIONS: FOV optimized and constrained undistorted single-shot DWI helps acquire high-resolution images of normal pituitary glands and pituitary macroadenomas with relatively few susceptibility artifacts in a clinically feasible scan time. This sequence might be helpful for evaluating the consistency of pituitary macroadenomas.FOCUSFOV optimized and constrained undistorted single-shot