RT Journal Article
SR Electronic
T1 Detection and characterization of atherosclerotic fibrous caps with T2-weighted MR.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 129
OP 134
VO 19
IS 1
A1 W B Winn
A1 U P Schmiedl
A1 D D Reichenbach
A1 K W Beach
A1 H Nghiem
A1 C Dimas
A1 E Daniel
A1 K R Maravilla
A1 C Yuan
YR 1998
UL http://www.ajnr.org/content/19/1/129.abstract
AB PURPOSE We assessed the performance of T2-weighted MR imaging in detecting atherosclerotic fibrous caps and in depicting their integrity.METHODS Twenty atherosclerotic lesions removed by carotid endarterectomy were imaged on a 1.5-T system using T2-weighted spin-echo sequences. The MR images were reviewed independently by four blinded interpreters for fibrous caps and ruptures. The results obtained from the observers were then graded against histologic findings by using receiver-operating characteristic (ROC) curve analysis.RESULTS The area under the ROC curve for fibrous cap detection was 0.80, indicating that T2-weighted MR imaging was a good but not definitively diagnostic test for detecting ex vivo fibrous caps. The ROC curve for fibrous cap characterization yielded an area of 0.75, indicating that T2-weighted MR imaging was a fair but not highly diagnostic test for depicting fibrous cap integrity. A definite reading for detection of fibrous caps or rupture was fairly specific (90% and 98%, respectively) but not very sensitive (37% and 12%, respectively).CONCLUSIONS T2-weighted MR imaging of ex vivo atherosclerotic plaques aided in the detection and evaluation of fibrous caps. In both cases, MR imaging proved more useful for ruling out disease than for confirming its presence.