@article {Lee1415, author = {B. Lee and J.E. Park and A. Bj{\o}rnerud and J.H. Kim and J.Y. Lee and H.S. Kim}, title = {Clinical Value of Vascular Permeability Estimates Using Dynamic Susceptibility Contrast MRI: Improved Diagnostic Performance in Distinguishing Hypervascular Primary CNS Lymphoma from Glioblastoma}, volume = {39}, number = {8}, pages = {1415--1422}, year = {2018}, doi = {10.3174/ajnr.A5732}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: A small subset of primary central nervous system lymphomas exhibits high cerebral blood volume, which is indistinguishable from that in glioblastoma on dynamic susceptibility contrast MR imaging. Our study aimed to test whether estimates of combined perfusion and vascular permeability metrics derived from DSC-MR imaging can improve the diagnostic performance in differentiating hypervascular primary central nervous system lymphoma from glioblastoma.MATERIALS AND METHODS: A total of 119 patients (with 30 primary central nervous system lymphomas and 89 glioblastomas) exhibited hypervascular foci using the reference method of leakage-corrected CBV (reference-normalized CBV). An alternative postprocessing method used the tissue residue function to calculate vascular permeability (extraction fraction), leakage-corrected CBV, cerebral blood flow, and mean transit time. Parameters were compared using Mann-Whitney U tests, and the diagnostic performance to distinguish primary central nervous system lymphoma from glioblastoma was calculated using the area under the curve from the receiver operating characteristic curve and was cross-validated with bootstrapping.RESULTS: Hypervascular primary central nervous system lymphoma showed similar leakage-corrected normalized CBV and leakage-corrected CBV compared with glioblastoma (P \> .05); however, primary central nervous system lymphoma exhibited a significantly higher extraction fraction (P \< .001) and CBF (P = .01) and shorter MTT (P \< .001) than glioblastoma. The extraction fraction showed the highest diagnostic performance (the area under the receiver operating characteristic curve [AUC], 0.78; 95\% confidence interval, 0.69{\textendash}0.85) for distinguishing hypervascular primary central nervous system lymphoma from glioblastoma, with a significantly higher performance than both CBV (AUC, 0.53{\textendash}0.59, largest P = .02) and CBF (AUC, 0.72) and MTT (AUC, 0.71).CONCLUSIONS: Estimation of vascular permeability with DSC-MR imaging further characterizes hypervascular primary central nervous system lymphoma and improves diagnostic performance in glioblastoma differentiation.AUCarea under the receiver operating characteristic curveCBVresleakage-corrected CBV derived using the proposed residue function{\textendash}based correction methodDCEdynamic contrast-enhancedEFextraction fractionKtranscontrast agent transfer constantnCBVrefleakage-corrected normalized CBV derived using the reference-correction methodPCNSLprimary central nervous system lymphoma}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/39/8/1415}, eprint = {https://www.ajnr.org/content/39/8/1415.full.pdf}, journal = {American Journal of Neuroradiology} }