TY - JOUR T1 - Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome. JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 415 LP - 417 VL - 19 IS - 3 AU - Y Ito AU - Y Arahata AU - Y Goto AU - M Hirayama AU - M Nagamutsu AU - T Yasuda AU - T Yanagi AU - G Sobue Y1 - 1998/03/01 UR - http://www.ajnr.org/content/19/3/415.abstract N2 - Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper-limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs. Our patient also had hypomagnesemia, which may have figured in the pathophysiology. ER -