PT  - JOURNAL ARTICLE
AU  - A J Barkovich
AU  - F A Ali
AU  - H A Rowley
AU  - N Bass
TI  - Imaging patterns of neonatal hypoglycemia.
DP  - 1998 Mar 01
TA  - American Journal of Neuroradiology
PG  - 523--528
VI  - 19
IP  - 3
4099  - http://www.ajnr.org/content/19/3/523.short
4100  - http://www.ajnr.org/content/19/3/523.full
SO  - Am. J. Neuroradiol.1998 Mar 01; 19
AB  - PURPOSE Our purpose was to report the patterns of injury observed in five patients who suffered brain damage consequent to neonatal hypoglycemia.METHODS The imaging studies and clinical records of five patients with brain damage caused by neonatal hypoglycemia were reviewed retrospectively. Patterns of injury were compared with those described in the literature and those seen in neonatal hypoxic-ischemic injury.RESULTS Diffuse cortical and subcortical white matter damage was seen, with the parietal and occipital lobes affected most severely. Globus pallidus injury was present in one patient who had the most severe cortical injury.CONCLUSION We found a specific pattern of injury that correlates well with the sparse pathologic and imaging reports on neonatal hypoglycemia. We speculate that the patterns of damage are the result of regional hypoperfusion and excitatory toxicity with cell-type-specific injury.