RT Journal Article SR Electronic T1 Effect of Gadolinium on the Estimation of Myelin and Brain Tissue Volumes Based on Quantitative Synthetic MRI JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology DO 10.3174/ajnr.A5921 A1 T. Maekawa A1 A. Hagiwara A1 M. Hori A1 C. Andica A1 T. Haruyama A1 M. Kuramochi A1 M. Nakazawa A1 S. Koshino A1 R. Irie A1 K. Kamagata A1 A. Wada A1 O. Abe A1 S. Aoki YR 2018 UL http://www.ajnr.org/content/early/2018/12/27/ajnr.A5921.abstract AB BACKGROUND AND PURPOSE: The effect of gadolinium on the estimation of myelin has not been reported. The aim of the current study was to investigate the effects of gadolinium on automatic myelin and brain tissue volumetry via quantitative synthetic MR imaging.MATERIALS AND METHODS: The study included 36 patients who were referred for brain metastases screening, and quantitative synthetic MR imaging data before and after gadolinium-based contrast agent administration were analyzed retrospectively. Brain metastases were detected in 17 patients. WM volume, GM volume, CSF volume, non-WM/GM/CSF volume, myelin volume, brain parenchymal volume, myelin fraction (myelin volume/brain parenchymal volume), and intracranial volume were estimated. T1 and T2 relaxation times, proton density, and myelin partial volume per voxel averaged across the brain parenchyma were also analyzed.RESULTS: In patients with and without metastases after gadolinium-based contrast agent administration, measurements of WM and myelin volumes, and myelin fraction were significantly increased (+26.65 and +29.42 mL, +10.14 and +12.46 mL, +0.88% and +1.09%, respectively), whereas measurements of GM, CSF, brain parenchymal, and intracranial volumes were significantly decreased (−36.23 and −34.49 mL, −20.77 and −18.94 mL, −6.76 and −2.84 mL, −27.41 and −21.84 mL, respectively). Non-WM/GM/CSF volume did not show a significant change. T1, T2, and proton density were significantly decreased (−51.34 and −46.84 ms, −2.67 and −4.70 ms, −1.05%, and −1.28%, respectively) after gadolinium-based contrast agent administration, whereas measurements of myelin partial volume were significantly increased (+0.78% and +0.75%, respectively).CONCLUSIONS: Gadolinium had a significant effect on the automatic calculation of myelin and brain tissue volumes using quantitative synthetic MR imaging, which can be explained by decreases in T1, T2, and proton density.GBCAgadolinium-based contrast agentICVintracranial volumePDproton densityT1longitudinal relaxation timeT2transverse relaxation timeVMYmyelin partial volume