TY - JOUR T1 - Y-Stent-Assisted Coiling of Wide-Neck Bifurcation Intracranial Aneurysms: A Meta-Analysis JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 122 LP - 128 DO - 10.3174/ajnr.A5900 VL - 40 IS - 1 AU - F. Cagnazzo AU - N. Limbucci AU - S. Nappini AU - L. Renieri AU - A. Rosi AU - A. Laiso AU - D. Tiziano di Carlo AU - P. Perrini AU - S. Mangiafico Y1 - 2019/01/01 UR - http://www.ajnr.org/content/40/1/122.abstract N2 - BACKGROUND: Y-stent-assisted coiling for wide-neck intracranial aneurysms required further investigation.PURPOSE: Our aim was to analyze outcomes after Y-stent placement in wide-neck aneurysms.DATA SOURCES: We performed a systematic search of 3 data bases for studies published from 2000 to 2018.STUDY SELECTION: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we included studies reporting Y-stent-assisted coiling of wide-neck aneurysms.DATA ANALYSIS: Random-effects meta-analysis was used to pool the following: aneurysm occlusion rate, complications, and factors influencing the studied outcomes.DATA SYNTHESIS: We included 27 studies and 750 aneurysms treated with Y-stent placement. The immediate complete/near-complete occlusion rate was 82.2% (352/468; 95% CI, 71.4%–93%; I2 = 92%), whereas the long-term complete/near-complete occlusion rate was 95.4% (564/598; 95% CI, 93.7%–97%; I2 = 0%) (mean radiologic follow-up of 14 months). The aneurysm recanalization rate was 3% (20/496; 95% CI, 1.5%–4.5%; I2 = 0%), and half of the recanalized aneurysms required retreatment. The treatment-related complication rate was 8.9% (63/614; 95% CI, 5.8%–12.1%; I2 = 44%). Morbidity and mortality after treatment were 2.4% (18/540; 95% CI, 1.2%–3.7%; I2 = 0%) and 1.1% (5/668; 95% CI, 0.3%–1.9%; I2 = 0%), respectively. Crossing Y-stent placement was associated with a slightly lower complication rate compared with the kissing configuration (56/572 = 8.4%; 95% CI, 5%–11%; I2 = 46% versus 4/30 = 12.7%; 95% CI, 3%–24%; I2 = 0%). Occlusion rates were quite comparable among Enterprise, Neuroform, and LVIS stents, whereas the Enterprise stent was associated with lower rates of complications (8/89 = 6.5%; 95% CI, 1.6%–11%; I2 = 0%) compared with the others (20/131 = 14%; 95% CI, 5%–26%; I2 = 69% and 9/64 = 11%; 95% CI, 3%–20%; I2 = 18%).LIMITATIONS: This was a small, retrospective series.CONCLUSIONS: Y-stent-assisted coiling yields high rates of long-term angiographic occlusion, with a relatively low rate of treatment-related complications. Y-stent placement with a crossing configuration appears to be associated with better outcomes. Although Y-configuration can be obtained using many types of stents with comparable occlusion rates, the Enterprise stent is associated with lower complication rates.IQRinterquartile rangePRISMAPreferred Reporting Items for Systematic Reviews and Meta-AnalysesSACstent-assisted coilingY-SACY-stent-assisted coiling ER -