TY - JOUR T1 - Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A5931 AU - R. Watts AU - J.M. Steinklein AU - L. Waldman AU - X. Zhou AU - C.G. Filippi Y1 - 2019/01/24 UR - http://www.ajnr.org/content/early/2019/01/24/ajnr.A5931.abstract N2 - SUMMARY: On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in the development of Alzheimer's disease. We report the first quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol with serial T1 mapping to produce contrast concentration maps up to 3 days postinjection, demonstrating performing a quantitative study using the techniques described feasibility and providing data on pharmacokinetics.ADAlzheimer's disease ER -