TY - JOUR T1 - High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 366 LP - 369 DO - 10.3174/ajnr.A5888 VL - 40 IS - 2 AU - C.D. Spyris AU - R.C. Castellino AU - M.J. Schniederjan AU - N. Kadom Y1 - 2019/02/01 UR - http://www.ajnr.org/content/40/2/366.abstract N2 - SUMMARY: High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.HGGhigh-grade gliomaLGGlow-grade gliomaNF1neurofibromatosis type 1 ER -