@article {Ivanidze, author = {J. Ivanidze and M. Mackay and A. Hoang and J.M. Chi and K. Cheng and C. Aranow and B. Volpe and B. Diamond and P.C. Sanelli}, title = {Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain}, year = {2019}, doi = {10.3174/ajnr.A5962}, publisher = {American Journal of Neuroradiology}, abstract = {SUMMARY: We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.BBBPblood-brain barrier permeabilityDCEdynamic contrast-enhancedKtransvolume transfer constantSLEsystemic lupus erythematosusVEvolume in the extravascular extracellular space}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/early/2019/02/07/ajnr.A5962}, eprint = {https://www.ajnr.org/content/early/2019/02/07/ajnr.A5962.full.pdf}, journal = {American Journal of Neuroradiology} }