PT  - JOURNAL ARTICLE
AU  - K. Buch
AU  - B. Baylosis
AU  - A. Fujita
AU  - M.M. Qureshi
AU  - K. Takumi
AU  - P.C. Weber
AU  - O. Sakai
TI  - Etiology-Specific Mineralization Patterns in Patients with Labyrinthitis Ossificans
AID  - 10.3174/ajnr.A5985
DP  - 2019 Feb 21
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2019/02/21/ajnr.A5985.short
4100  - http://www.ajnr.org/content/early/2019/02/21/ajnr.A5985.full
AB  - BACKGROUND AND PURPOSE: Our aim was to identify whether specific patterns of ossification in labyrinthitis ossificans are associated with the known risk factors. Labyrinthitis ossificans has been described as sequela of prior temporal bone trauma, prior infection, and other disorders including sickle cell disease. Specific patterns of mineralization in the membranous labyrinth associated with these risk factors has not been previously described.MATERIALS AND METHODS: This was a retrospective study evaluating temporal bone CT scans at our institution from November 2005 to May 2018 in patients with labyrinthitis ossificans. Membranous labyrinthine structures evaluated for ossification included the following: basal, middle, and apical cochlear turns; lateral, posterior, and superior semicircular canals; and the vestibule for both ears in all patients. These structures were assigned a severity score, 0–4, based on degree of mineralization. Clinical records were reviewed for potential labyrinthitis ossificans risk factors. Basic descriptive statistics and a mixed model were used to correlate the degree and patterns of ossification with clinical history.RESULTS: Forty-four patients (58 ears) with labyrinthitis ossificans were identified and evaluated. The most common risk factors were chronic otomastoiditis (n = 18), temporal bone surgery (n = 9), temporal bone trauma (n = 6), sickle cell disease (n = 5), and meningitis (n = 4). For all etiologies, the semicircular canals were most severely affected, and the vestibule was the least. In patients with prior temporal bone surgery, significantly greater mineralization was seen in the basal turn of the cochlea (P = .027), the vestibule (P = .001), and semicircular canals (P < .001–.008). No significant pattern was identified in patients with meningitis, sickle cell disease, or trauma.CONCLUSIONS: Significant patterns of mineralization in labyrinthitis ossificans were observed in patients with prior temporal bone surgery. For all etiologies, the semicircular canals were most severely affected. No significant mineralization pattern was observed in patients with chronic otomastoiditis, meningitis, sickle cell disease, or prior temporal bone trauma.AAO-HNSAmerican Academy of Otolaryngology–Head and Neck SurgeryLOlabyrinthitis ossificans