TY - JOUR T1 - Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 408 LP - 411 DO - 10.3174/ajnr.A5962 VL - 40 IS - 3 AU - J. Ivanidze AU - M. Mackay AU - A. Hoang AU - J.M. Chi AU - K. Cheng AU - C. Aranow AU - B. Volpe AU - B. Diamond AU - P.C. Sanelli Y1 - 2019/03/01 UR - http://www.ajnr.org/content/40/3/408.abstract N2 - SUMMARY: We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.BBBPblood-brain barrier permeabilityDCEdynamic contrast-enhancedKtransvolume transfer constantSLEsystemic lupus erythematosusVEvolume in the extravascular extracellular space ER -