RT Journal Article
SR Electronic
T1 Diagnostic Utility of Optic Nerve Measurements with MRI in Patients with Optic Nerve Atrophy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 558
OP 561
DO 10.3174/ajnr.A5975
VO 40
IS 3
A1 B. Zhao
A1 N. Torun
A1 M. Elsayed
A1 A.-D. Cheng
A1 A. Brook
A1 Y.-M. Chang
A1 R.A. Bhadelia
YR 2019
UL http://www.ajnr.org/content/40/3/558.abstract
AB BACKGROUND AND PURPOSE: No MR imaging measurement criteria are available for the diagnosis of optic nerve atrophy. We determined a threshold optic nerve area on MR imaging that predicts a clinical diagnosis of optic nerve atrophy and assessed the relationship between optic nerve area and retinal nerve fiber layer thickness measured by optical coherence tomography, an ancillary test used to evaluate optic nerve disorders.MATERIALS AND METHODS: We evaluated 26 patients with suspected optic nerve atrophy (8 with unilateral, 13 with bilateral and 5 with suspected but not demonstrable optic nerve atrophy) who had both orbital MR imaging and optical coherence tomography examinations. Forty-five patients without optic nerve atrophy served as controls. Coronal inversion recovery images were used to measure optic nerve area on MR imaging. Retinal nerve fiber layer thickness was determined by optical coherence tomography. Individual eyes were treated separately; however, bootstrapping was used to account for clustering when appropriate. Correlation coefficients were used to evaluate relationships; receiver operating characteristic curves, to investigate predictive accuracy.RESULTS: There was a significant difference in optic nerve area between patients' affected eyes with optic nerve atrophy (mean, 3.09 ± 1.09 mm2), patients' unaffected eyes (mean, 5.27 ± 1.39 mm2; P = .008), and control eyes (mean, 6.27 ± 2.64 mm2; P < .001). Optic nerve area ≤ 4.0 mm2 had a sensitivity of 0.85 and a specificity of 0.83 in predicting the diagnosis of optic nerve atrophy. A significant relationship was found between optic nerve area and retinal nerve fiber layer thickness (r = 0.68, P < .001).CONCLUSIONS: MR imaging–measured optic nerve area ≤ 4.0 mm2 has moderately high sensitivity and specificity for predicting optic nerve atrophy, making it a potential diagnostic tool for radiologists.OCToptical coherence tomographyONAoptic nerve atrophyONareaoptic nerve areaRNFLretinal nerve fiber layerROCreceiver operating characteristic