TY - JOUR T1 - Quantification of DTI in the Pediatric Spinal Cord: Application to Clinical Evaluation in a Healthy Patient Population JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A6104 AU - B.B. Reynolds AU - S. By AU - Q.R. Weinberg AU - A.A. Witt AU - A.T. Newton AU - H.R. Feiler AU - B. Ramkorun AU - D.B. Clayton AU - P. Couture AU - J.E. Martus AU - M. Adams AU - J.C. Wellons III AU - S.A. Smith AU - A. Bhatia Y1 - 2019/06/13 UR - http://www.ajnr.org/content/early/2019/06/13/ajnr.A6104.abstract N2 - BACKGROUND AND PURPOSE: The purpose of the study is to characterize diffusion tensor imaging indices in the developing spinal cord, evaluating differences based on age and cord region. Describing the progression of DTI indices in the pediatric cord increases our understanding of spinal cord development.MATERIALS AND METHODS: A retrospective analysis was performed on DTI acquired in 121 pediatric patients (mean, 8.6 years; range, 0.3–18.0 years) at Monroe Carell Jr. Children's Hospital at Vanderbilt from 2017 to 2018. Diffusion-weighted images (15 directions; b = 750 s/mm2; slice thickness, 5 mm; in-plane resolution, 1.0 × 1.0 mm2) were acquired on a 3T scanner in the cervicothoracic and/or thoracolumbar cord. Manual whole-cord segmentation was performed. Images were masked and further segmented into cervical, upper thoracic, thoracolumbar, and conus regions. Analyses of covariance were performed for each DTI-derived index to investigate how age affects diffusion across cord regions, and 95% confidence intervals were calculated across age for each derived index and region. Post hoc testing was performed to analyze regional differences.RESULTS: Analyses of covariance revealed significant correlations of age with axial diffusivity, mean diffusivity, and fractional anisotropy (all, P < .001). There were also significant differences among cord regions for axial diffusivity, radial diffusivity, mean diffusivity, and fractional anisotropy (all, P < .001).CONCLUSIONS: This research demonstrates that diffusion evolves in the pediatric spinal cord during development, dependent on both cord region and the diffusion index of interest. Future research could investigate how diffusion may be affected by common pediatric spinal pathologies.ADaxial diffusivityANCOVAanalyses of covarianceDTIdiffusion tensor imagingEPIecho planar imagingFAfractional anisotropyFOVfield-of-viewGMgray matterMDmean diffusivityPMMpopulation marginal meansRDradial diffusivitySNRsignal to noise ratioWMwhite matter ER -