PT - JOURNAL ARTICLE AU - J. Takanashi AU - M. Kanazawa AU - Y. Kohno TI - Central Tegmental Tract Involvement in an Infant with 6-Pyruvoyltetrahydropterin Synthetase Deficiency DP - 2006 Mar 01 TA - American Journal of Neuroradiology PG - 584--585 VI - 27 IP - 3 4099 - http://www.ajnr.org/content/27/3/584.short 4100 - http://www.ajnr.org/content/27/3/584.full SO - Am. J. Neuroradiol.2006 Mar 01; 27 AB - Summary: We report the case of an asymptomatic 2-month-old infant with 6-pyruvoyltetrahydropterin synthetase deficiency detected through a neonatal phenylketonuria screening program. MR imaging revealed symmetrical lesions in the central tegmental tract with reduced diffusion, which resolved after treatment. A possible explanation for these lesions is intramyelinic edema resulting from brain insults in utero.