TY - JOUR T1 - Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1304 LP - 1308 DO - 10.3174/ajnr.A6116 VL - 40 IS - 8 AU - J.A. Galnares-Olalde AU - A.J. Vázquez-Mézquita AU - G. Gómez-Garza AU - D. Reyes-Vázquez AU - V. Higuera-Ortiz AU - M.A. Alegría-Loyola AU - A. Mendez-Dominguez Y1 - 2019/08/01 UR - http://www.ajnr.org/content/40/8/1304.abstract N2 - SUMMARY: Consumption of over-the-counter dietary supplements to reduce body weight is common among the population. Thermogenics are herbal combinations that claim to produce a fat-burning process through an increase in the cellular metabolic rate and greater cellular energy consumption, having a high risk for patients developing toxic leukoencephalopathy. We present a series of 6 patients with acute neurologic symptoms and MR imaging showing restricted diffusion and decreased apparent diffusion coefficient values (mean value, 400 mm2/s × 10−6) in the entire corpus callosum compatible with a cytotoxic lesion of the corpus callosum. Although patients responded favorably to the product discontinuation with rapid recovery of neurologic symptoms, there was a more prolonged resolution on imaging alterations. Because of the widespread availability and unregulated nature of thermogenic dietary supplements, physicians must be aware of the clinical and radiologic characteristics of these potential complications of their use.CLOCCcytotoxic lesion of the corpus callosum ER -