TY - JOUR T1 - Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1481 LP - 1483 DO - 10.3174/ajnr.A6145 VL - 40 IS - 9 AU - W.M. Freeze AU - D.N. ter Weele AU - W.M. Palm AU - R.W. van Hooren AU - E.I. Hoff AU - J.F.A. Jansen AU - H.I.L. Jacobs AU - F.R. Verhey AU - W.H. Backes Y1 - 2019/09/01 UR - http://www.ajnr.org/content/40/9/1481.abstract N2 - SUMMARY: Pericortical enhancement on postcontrast FLAIR images is a marker for subtle leptomeningeal blood-brain barrier leakage. We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. On the basis of phantom experiments and human in vivo data, we showed that detection of subtle pericortical enhancement can be facilitated by using a relatively long TE. Future studies should choose their FLAIR sequence parameters carefully when assessing pericortical enhancement due to subtle blood-brain barrier leakage.BBBblood-brain barrierpcpostcontrast ER -