RT Journal Article
SR Electronic
T1 Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1481
OP 1483
DO 10.3174/ajnr.A6145
VO 40
IS 9
A1 W.M. Freeze
A1 D.N. ter Weele
A1 W.M. Palm
A1 R.W. van Hooren
A1 E.I. Hoff
A1 J.F.A. Jansen
A1 H.I.L. Jacobs
A1 F.R. Verhey
A1 W.H. Backes
YR 2019
UL http://www.ajnr.org/content/40/9/1481.abstract
AB SUMMARY: Pericortical enhancement on postcontrast FLAIR images is a marker for subtle leptomeningeal blood-brain barrier leakage. We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. On the basis of phantom experiments and human in vivo data, we showed that detection of subtle pericortical enhancement can be facilitated by using a relatively long TE. Future studies should choose their FLAIR sequence parameters carefully when assessing pericortical enhancement due to subtle blood-brain barrier leakage.BBBblood-brain barrierpcpostcontrast