RT Journal Article
SR Electronic
T1 The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1015
OP 1021
DO 10.3174/ajnr.A0521
VO 28
IS 6
A1 A.I. Bartha
A1 K.R.L. Yap
A1 S.P. Miller
A1 R.J. Jeremy
A1 M. Nishimoto
A1 D.B. Vigneron
A1 A.J. Barkovich
A1 D.M. Ferriero
YR 2007
UL http://www.ajnr.org/content/28/6/1015.abstract
AB BACKGROUND AND PURPOSE: There is a lack of normative diffusion tensor imaging (DTI) and 3D MR spectroscopy (MRS) data in the early neonatal period. We report quantitative values from a cohort of healthy term neonates to serve as baseline data for studies assessing brain development and injury.MATERIALS AND METHODS: Sixteen healthy term neonates (median age, 7 days) were studied with spin-echo T1- and T2-weighted MR imaging, DTI, and 3D point-resolved spectroscopy sequence (PRESS) MRS without sedation on a 1.5T scanner. Average diffusivity (Dav), fractional anisotropy (FA), eigenvalues (EV), and metabolite ratios (N-acetylaspartate [NAA]/choline, lactate/choline) were calculated by automated processing in 7 brain regions. Neurodevelopment was assessed by blinded and validated neuromotor examinations and the Bayley II test at 3 and 14 months.RESULTS: Two neonates were excluded from the cohort: one had brain injury on T2-weighted imaging, and the other, who had normal MR imaging, showed mildly delayed cognition at 14 months. The mean DTI values of the remaining 14 neonates were between these ranges: Dav=0.98–1.48 10−3 mm2/s, FA=0.14–0.30, EV1=1.21–1.88, EV2=0.95–1.46, and EV3=0.77–1.24 (all × 10−3 mm2/s). The NAA/choline ratio ranged between 0.58 and 0.73, and minimal lactate/choline (<0.15) could be detected in each neonate. All neonates exhibited clinically normal neuromotor status.CONCLUSIONS: Our study demonstrates the feasibility of obtaining high-quality quantifiable MR data in nonsedated healthy term neonates that can be used to study normal early brain development and as control data in studies of perinatal brain injury.