TY - JOUR T1 - Carotid Intraplaque-Hemorrhage Volume and Its Association with Cerebrovascular Events JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1731 LP - 1737 DO - 10.3174/ajnr.A6189 VL - 40 IS - 10 AU - L. Saba AU - G. Micheletti AU - W. Brinjikji AU - P. Garofalo AU - R. Montisci AU - A. Balestrieri AU - J.S. Suri AU - J.K. DeMarco AU - G. Lanzino AU - R. Sanfilippo Y1 - 2019/10/01 UR - http://www.ajnr.org/content/40/10/1731.abstract N2 - BACKGROUND AND PURPOSE: Our aim was to assess the relationship between volume and percentage of intraplaque hemorrhage measured using CT and the occurrence of cerebrovascular events at the time of CT.MATERIALS AND METHODS: One-hundred-twenty-three consecutive subjects (246 carotid arteries) with a mean age of 69 years who underwent CTA were included in this retrospective study. Plaque volume of components and subcomponents (including intraplaque hemorrhage volume) was quantified with dedicated software.RESULTS: Forty-six arteries were excluded because no plaque was identified. In the remaining 200 carotid arteries, a statistically significant difference was found between presentation with cerebrovascular events and lipid volume (P = .002), intraplaque hemorrhage volume (P = .002), percentage of lipid (P = .002), percentage of calcium (P = .001), percentage of intraplaque hemorrhage (P = .001), percentage of lipid-intraplaque hemorrhage (P = .001), and intraplaque hemorrhage/lipid ratio (P = .001). The highest receiver operating characteristic area under the curve was obtained with the intraplaque hemorrhage volume with a value of 0.793 (P = .001), percentage of intraplaque hemorrhage with an area under the curve of 0.812 (P = .001), and the intraplaque hemorrhage/lipid ratio with an area under the curve value of 0.811 (P = .001).CONCLUSIONS: Results of our study suggest that Hounsfield unit values <25 have a statistically significant association with the presence of cerebrovascular events and that the ratio intraplaque hemorrhage/lipid volume represents a strong parameter for the association of cerebrovascular events.AUCarea under the curveIPHintraplaque hemorrhageROCreceiver operating characteristic ER -