RT Journal Article SR Electronic T1 Combined Pituitary Hormone Deficiency and PROP-1 Mutation in Two Siblings: A Distinct MR Imaging Pattern of Pituitary Enlargement JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1369 OP 1370 DO 10.3174/ajnr.A0545 VO 28 IS 7 A1 L.L.F. do Amaral A1 R.M. Ferreira A1 N.P.F.D. Ferreira A1 R.A. Mendonça A1 V.H.R. Marussi A1 J.L. da Cunha A1 B.R. Maçaranduba A1 J.D. Medeiros YR 2007 UL http://www.ajnr.org/content/28/7/1369.abstract AB SUMMARY: Mutations of the PROP-1 gene are the most frequent genetic defect in patients with combined pituitary hormone insufficiency. We present the cases of 2 siblings with PROP-1 mutations whom we observed longitudinally. Their initial pituitary MR imaging examinations showed identical findings: an enlarged adenohypophysis, with striking hypointensity on T2-weighted images and slight hyperintensity on T1-weighted images. In one of the children, the follow-up MR imaging obtained 3 years after hormonal replacement revealed a decrease in the size of the anterior pituitary lobe.