TY - JOUR T1 - Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 2016 LP - 2022 DO - 10.3174/ajnr.A6308 VL - 40 IS - 12 AU - M.H.T. Zwartbol AU - M.I. Geerlings AU - R. Ghaznawi AU - J. Hendrikse AU - A.G. van der Kolk AU - on behalf of the UCC-SMART Study Group Y1 - 2019/12/01 UR - http://www.ajnr.org/content/40/12/2016.abstract N2 - BACKGROUND AND PURPOSE: Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship in vivo are sparse and report inconsistent results. We studied the relationship between intracranial atherosclerosis and extracranial atherosclerosis in a cohort of patients with a history of vascular disease.MATERIALS AND METHODS: Within the Second Manifestations of ARTerial disease–Magnetic Resonance (SMART) study, cross-sectional analyses were performed in 130 patients (mean age, 68 ± 9 years) with a history of vascular disease and with assessable 7T intracranial vessel wall MR imaging data. Intracranial atherosclerosis burden was defined as the number of intracranial vessel wall lesions in the circle of Willis and its major branches. Age- and sex-adjusted unstandardized regression coefficients (b-value) were calculated with intracranial atherosclerosis burden as the dependent variable and extracranial atherosclerosis markers as independent variables.RESULTS: Ninety-six percent of patients had ≥1 vessel wall lesion, with a mean intracranial atherosclerosis burden of 8.5 ± 5.7 lesions. Significant associations were observed between higher intracranial atherosclerosis burden and carotid intima-media thickness (b = 0.53 lesions per +0.1  mm; 95% CI, 0.1–1.0 lesions), 50%–100% carotid stenosis versus no stenosis (b = 6.6 lesions; 95% CI, 2.3–10.9 lesions), ankle-brachial index ≤ 0.9 versus >0.9 (b = 4.9 lesions; 95% CI, 1.7–8.0 lesions), and estimated glomerular filtration rate (b = –0.77 lesions per +10 mL/min; 95% CI, −1.50 to −0.03 lesions). No significant differences in intracranial atherosclerosis burden were found among different categories of vascular disease.CONCLUSIONS: Intracranial atherosclerosis was associated with various extracranial markers of atherosclerosis, not supporting a different etiology.ABIankle-brachial indexcIMTcarotid intima-media thicknessECASextracranial atherosclerosiseGFRestimated glomerular filtration rateICASintracranial atherosclerosis ER -